Journal: Physics in medicine and biology
Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping
doi: 10.1088/0031-9155/61/24/8476
Figure Lengend Snippet: (a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.
Article Snippet: C. Receiver Array Characterization: Passive Microbubble Imaging The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (Definity™, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).
Techniques: In Situ, Ex Vivo, Generated
![(a) Lateral (top row) and axial (bottom row) images of <t>microbubble</t> clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_5599/pmc05135599/pmc05135599__nihms-831851-f0010.jpg)
